胞质DNA的出现通常会触发天然免疫应答，但细胞同时必须避免将自身来源的DNA误识别为危险信号。维持这一平衡对于限制慢性炎症、自身免疫及相关病理过程至关重要。TREX1是这一过程中的关键核酸酶，长期以来被认为主要通过降解胞质DNA来抑制cGAS-STI ...

减数分裂同源重组起始于SPO11-TOP6BL及其辅助蛋白介导的程序性DNA双链断裂（double-strand break，DSB）。DSB的分布具有偏好性，那些高频发生DSB的区域被称为热点。在大多数哺乳动物中，热点由减数分裂特异性组蛋白甲基转移酶PRDM9决定。减数分裂DSB形成的精确时空调控对于遗传多样性和基因组稳定性的维持至关重要。该过程的异常会导致异常重组、染色体错误分离和生殖障碍。

Scientists at Stanford University have discovered that DRT3, a unique defense system found in bacteria, creates DNA to ...

A double-strand break (DSB) is a type of DNA damage where both strands of the DNA helix are cut or broken at the same location, causing a complete discontinuity in the DNA molecule. Unrepaired or ...

When a gene is turned on in a cell, it creates a ripple effect along the DNA strand, changing the physical structure of the ...

A new prime assembly technique inserts DNA segments up to 11,000 base pairs into the genome, enabling correction of thousands ...

Serif Biomedicines has emerged from stealth with $50 million in start-up funding. The new firm is developing what it calls ...