Multiple forms of double-stranded RNA (blue, magenta, orange structures) cross cell membranes with the help of a conserved protein located in novel sites (colored by depth) throughout the roundworm's ...

There are many molecules with therapeutic potential, but it can be a challenge to deliver them to the right places at the right times. RNA is one such molecule; the sequences for different proteins ...

Building on its success against COVID-19, mRNA technology holds promise for novel vaccines and treatments targeting various diseases. However, a critical challenge remains: current in vitro ...

RNA-based medicines are one of the most promising ways to fight human disease, as demonstrated by the recent successes of RNA vaccines and double-stranded RNA (dsRNA) therapies. But while health care ...

A new study by scientists at Hokkaido University has found that lower temperatures significantly increase the risk of gastroenteritis among Rohingya refugees living in Bangladesh's Kutupalong and ...

Double-stranded RNA (dsRNA) is a critical immunostimulatory impurity in mRNA production and poses a problem for the downstream purification methods vital to manufacturing mRNA vaccines and ...

A forested hill and clouds are in the background of an image of a shallow pool of steaming water, with the ground underneath colored in shades of beige, red, and brown. Life may have first emerged in ...

Francesca Storici consults at Tessera Therapeutics. She has received funding from the National Institutes of Health and the National Science Foundation. Your DNA is continually damaged by sources both ...

As RNA therapeutics evolve far beyond their vaccine origins, a new generation of scientists and manufacturers is rethinking how to produce these complex medicines safely, efficiently, and at scale.