Researchers have found an enzyme that can turn fragile drug molecules into durable ring shapes. This could help medications like Ozempic last longer and work more effectively. The process is simpler ...

Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases, including ...

Proteins are the workers in a cell and, as the "basic element of life", are responsible for the most widely varying metabolic processes. In plants, for example, they take on an important function in ...

The molecular structure of an enzyme from a marine bacterium with potential industrial uses has been determined by RIKEN ...

Sanofi has developed a simpler way to create site-specific antibody-to-mannose-6-phosphate (M6P) conjugates that eliminates the need for enzyme remodeling. This more straightforward method makes M6P ...

This method uses polymer modifications to tune enzyme activity for increased solubility in non-native solvents. Tuning the miscibility of enzymes in non-native solvent environments has important ...

Archaeosine is synthesized via three steps in tRNA. ArcS, the second-step enzyme, transfers a lysine to preQ 0, which is introduced into tRNA by ArcTGT, the first-step enzyme. The resultant preQ 0-Lys ...

Scientists have identified the enzyme YcaO in E. coli as solely responsible for thioamidating the ribosomal protein uL16, a modification absent in humans but present in several harmful bacteria. This ...

RNA epigenetics also called Epitranscriptomics is an evolving field of research that explores chemical modifications on RNA and their impact on the cell and ...

Scientists have pinpointed the enzyme YcaO as responsible for a rare ribosomal protein modification in several pathogenic bacteria, a process absent in humans. The finding could open new avenues for ...