我们的基因组每时每刻都在遭受着来自紫外线（UV）、化学物质以及自身代谢产物的攻击。为了维持遗传信息的完整性，细胞进化出了一套令人叹为观止的防御机制——核苷酸切除修复（Nucleotide Excision Repair, NER）。 这套机制的失灵，直接导致了着色性干皮病 ...

Nucleotide excision repair (NER) is a major conserved DNA repair pathway, which repairs various types of damage in the genome, such as those induced by ultraviolet light and environmental agents.

A new study by researchers from the Gwangju Institute of Science and Technology in the Republic of Korea has revealed the mechanism of DNA repair by enzymes exonuclease III and polymerase I by ...

Researchers decode repair mechanism during transcription of genetic information. Cockayne syndrome is a severe autosomal recessive disorder caused by defective DNA repair mechanisms. People with the ...

Efficacy of novel proteasome inhibitory platinum complex against osteosarcoma. This is an ASCO Meeting Abstract from the 2014 ASCO Annual Meeting I. This abstract does not include a full text ...

(Nanowerk News) A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA. Such mistakes are frequent in code-copying process in ...

Transcription factor IIH, or TFIIH, pronounced "TF two H," is a veritable workhorse among the protein complexes that control human cell activity. It plays critical roles both in transcription—the ...

The Summit supercomputer revealed how damaged strands of DNA are surgically repaired by a molecular pathway called nucleotide excision repair, or NER. NER’s protein components can change shape to ...

Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma: CALGB 500104 No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2006 ASCO ...

A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA. A new study adds to an emerging, radically new picture of how bacterial ...