Wortmannin（渥曼青霉素，AbMole，M2053）是一种源自真菌的甾体代谢物，作为磷脂酰肌醇3-激酶（PI3K）家族的强效共价抑制剂，能不可逆地结合PI3K催化亚基。Wortmannin还能抑制同属PI3K家族的DNA依赖性蛋白激酶（DNA-PK）和共济失调毛细血管扩张症突变激酶（ATM）。在生物学活性上，Wortmannin（渥曼青霉素，AbMole，M2053） ...

Chief Executive Officer Brian Sullivan outlined the company’s clinical and commercial priorities for its lead asset, ...

Oral presentation of Ph 1a clinical data highlights potential best-in-class drug profile in heavily pretreated patients with PI3Ka-mutant ...

Antioxidant-1 may promote HCC carcinogenesis through the activation of the c-Myb/PI3K/AKT pathway and the inhibition of copper accumulation and oxidative stress. Despite advancements in diagnostic and ...

A team of researchers from the Badalona Applied Research Group in Oncology (B·ARGO) and the Urologic Tumours Unit of the Institut Català d'Oncologia (ICO) and the Germans Trias i Pujol Research ...

Please provide your email address to receive an email when new articles are posted on . Low-dose aspirin significantly reduced risk for colorectal cancer recurrence among patients with mutations in ...

Hutchmed begins global clinical trial of PI3K/PIKK-EGFR ATTC candidate HMPL-A580 in patients with solid tumours: Hong Kong, Shanghai Friday, March 6, 2026, 10:00 Hrs [IST] Hutchme ...

An international research team has identified a previously unknown mechanism by which the breast cancer drug tamoxifen can increase the risk of secondary tumors in the uterus. The study shows that ...