Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as non-alcoholic fatty liver disease) is a leading cause of chronic liver disease worldwide. MASLD can progress to ...

Spatially resolved transcriptomics (SRT) techniques have revolutionized the ability to perform high-throughput sequencing of mRNA while preserving spatial information in multicellular organisms 1,2,3.

The rapid development of spatial transcriptomics (ST) technologies has greatly advanced the understanding of gene expression, tissue architecture, cellular composition, and disease mechanisms within ...

Illumina's spatial transcriptomics offering is slated to provide analyses of millions of cells per experiment across a 50 mm by 15 mm imaging area. (Pixabay) Illumina is raising the curtain on its ...

Spatial transcriptomics provides a unique perspective on the genes that cells express and where those cells are located. However, the rapid growth of the technology has come at the cost of ...

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche cellular interactions in the gastrointestinal tract that promote the ...

Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...

Applying single-cell RNA sequencing has led researchers to be able to profile the entire transcriptome of cells. However, these transcriptomes prove difficult to link back to their original location ...

Breakthrough research details how distinct tissue niches and cell communication contribute to chronic active lesions in MS. Study: Cell type mapping reveals tissue niches and interactions in ...

Enhancing a low-cost, minimally invasive screening test for dihydropyrimidine dehydrogenase mutations linked to 5-fluorouracil sensitivity by integrating computational mutation predictions. This is an ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...