Monoclonal antibodies are widely used to treat diseases ranging from cancer to autoimmune disorders. The safety and efficacy ...

The first and largest dataset of genomic structure variations specific to childhood cancers was published today by scientists ...

Genomic structural variants (SVs) involve the rearrangement of DNA sequences and have the potential to drive phenotypic changes across the tree of life. The discovery of structural variation dates ...

Researchers still do not have a comprehensive picture of the factors that influence gene expression in human cancers. Understanding gene expression in cancer is important because it can reveal how the ...

Genome assemblies from 65 individuals, representing a variety of the world’s populations, are advancing the scientific exploration of complex genetic structural variation. Structural variations are ...

Papaya (Carica papaya L.) is a globally important tropical fruit valued for its nutrition and medicinal properties, yet its genetic diversity has been incompletely understood. In a new study, ...

Chong’s study, “Deciphering the exact breakpoints of structural variations using long sequencing reads with DeBreak,” was recently published in Nature Communications. UAB researchers have developed a ...

Assessments of DNA misrepair, and the resulting effects on the structural integrity of the genome, are critical for evaluating the safety of cell and gene therapy applications. Most genome editing ...

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought. The ...