来自国内外的研究人员针对DNA损伤修复与代谢调控的交叉机制展开研究,发现波形蛋白(Vimentin)通过结合Ku蛋白促进DNA双链断裂(DSB)的非同源末端连接(NHEJ)修复,同时抑制脂肪甘油三酯脂肪酶(ATGL)调控DNA损伤诱导的脂解。该研究揭示了Vimentin在癌症治疗 ...
推荐:本研究揭示了镉(Cd)暴露通过抑制SIRT6激活AKT/PI3K信号通路,导致vimentin磷酸化(p-Vim)和细胞外释放(eVim),进而促进COPD气道 ...
1月22日,首都医科大学宣武医院神经内科郝峻巍教授团队在JAMA Neurology发表研究论文,该研究利用高通量单细胞免疫组库技术,首次发现了脑脊液中存在靶向星形胶质细胞波形蛋白(Vimentin)自身抗体,并提出一种与该自身抗体相关的新型脑膜脑脊髓炎综合征。
在一项新的研究中,来自美国波士顿大学医学院的研究人员确定了细胞外的波形蛋白(vimentin)是促进SARS-CoV-2进入人体细胞的一种附着因子。作为一种结构蛋白,波形蛋白广泛表达于间质来源的细胞,如内皮细胞,是一种潜在的抗SARS-CoV-2的新靶点,有望用于阻断 ...
Tumour epithelial vimentin expression is a marker of mesenchymal differentiation and may be a useful marker of carcinomas with more aggressive behaviour. The aim of this study was to determine the ...
近日,中国农业科学院哈尔滨兽医研究所发现了波形蛋白(Vimentin)是非洲猪瘟病毒基因组DNA诱导炎症反应的识别受体,相关研究成果发表在《免疫学杂志(Journal of Immunology)》期刊上。 先天免疫系统能快速识别外源病原体及内源危险信号,从而启动有效的宿主 ...
A recent study has found that extracellular vimentin can bind to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein in vitro, and antibodies against vimentin can decrease ...
A phase II trial of trastuzumab combined with irinotecan in patients with advanced HER2-positive chemo-refractory gastric cancer: OGSG1203 (HERBIS-5). This is an ASCO Meeting Abstract from the 2016 ...
Vimentin intermediate filaments are generally present in mesenchymal cells. Vimentin is found not only in eukaryotic cells, but also in bacteria, where it helps to form the cytoskeleton. Vimentin is ...
There are three main kinds of cytoskeletal filaments: microfilaments, microtubules, and intermediate filaments in Eukaryotic cells. Intermediate filaments help to provide structure to cells, and are ...