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BMP-2 vs PDGF for nonunions — this new Bone & Joint Journal study finally gives us a head-to-head comparison using clinically relevant carriers. And the results weren’t even close. In a critical-sized femoral defect model, BMP-2 achieved 100% radiographic union, complete cortical bridging on micro-CT, and the only biomechanically meaningful bone across the defect. PDGF? Only 20% radiographic union and essentially no measurable mechanical strength in torsion testing. That aligns with what we see
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